{"id":6024,"date":"2023-12-29T12:54:18","date_gmt":"2023-12-29T17:54:18","guid":{"rendered":"https:\/\/newswz.com\/?p=6024"},"modified":"2024-01-27T01:11:34","modified_gmt":"2024-01-27T06:11:34","slug":"%e7%a0%94%e5%8f%91%e9%a6%96%e5%88%9b%e6%96%b0%e8%8d%af%e7%9a%84%e5%9b%b0%e9%9a%be%ef%bc%9a%e4%b8%ad%e5%9b%bd%e4%b8%ba%e4%bb%80%e4%b9%88%e9%9a%be%e6%9c%89%e9%a6%96%e5%88%9b%e6%96%b0%e8%8d%af%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/newswz.com\/?p=6024","title":{"rendered":"\u7814\u53d1\u9996\u521b\u65b0\u836f\u7684\u56f0\u96be\uff1a\u4e2d\u56fd\u4e3a\u4ec0\u4e48\u96be\u6709\u9996\u521b\u65b0\u836f\uff1f"},"content":{"rendered":"\n<p>\u56fe\u6e90\uff1apixabay<\/p>\n\n\n\n<p>\u6587\u7ae0\u6765\u6e90: \u817e\u8baf \u2013 \u65b0\u95fb\u53d6\u81ea\u5404\u5927\u65b0\u95fb\u5a92\u4f53\uff0c\u65b0\u95fb\u5185\u5bb9\u5e76\u4e0d\u4ee3\u8868\u672c\u7f51\u7acb\u573a\uff01<\/p>\n\n\n\n<p>\u9996\u521b\u65b0\u836f\uff08First in Class &#8211; 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class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"864\" height=\"273\" src=\"https:\/\/newswz.com\/wp-content\/uploads\/2023\/12\/641-2-1.webp\" alt=\"\" class=\"wp-image-6025\" srcset=\"https:\/\/newswz.com\/wp-content\/uploads\/2023\/12\/641-2-1.webp 864w, https:\/\/newswz.com\/wp-content\/uploads\/2023\/12\/641-2-1-300x95.webp 300w, https:\/\/newswz.com\/wp-content\/uploads\/2023\/12\/641-2-1-768x243.webp 768w, https:\/\/newswz.com\/wp-content\/uploads\/2023\/12\/641-2-1-585x185.webp 585w\" sizes=\"(max-width: 864px) 100vw, 864px\" \/><\/figure>\n\n\n\n<p>Fierce Pharma 2023 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laxative\uff09\uff1b10\u5e74\u4e4b\u95f4NIH\u603b\u5171\u82b1\u8d391870\u4ebf\u7f8e\u91d1\u7528\u4e8e\u836f\u7269\u4f5c\u7528\u9776\u70b9\u7684\u57fa\u7840\u6027\u7814\u7a76\u548c\u4ea7\u54c1\u7684\u5e94\u7528\u7814\u7a76\u3002[3]\u56e0\u6b64\uff0c\u5728\u8d22\u653f\u7684\u6276\u6301\u4e0b\uff0c\u7f8e\u56fd\u4ecd\u5728\u751f\u7269\u533b\u836f\u9886\u57df\u4e2d\u5904\u4e8e\u4e16\u754c\u7684\u9886\u5148\u9738\u4e3b\u5730\u4f4d\u3002\u636e\u7edf\u8ba1\uff0c2021\u5e74\u5168\u7403\u670984\u79cd\u65b0\u6d3b\u6027\u7269\u8d28\uff08NAS\uff09\u4e0a\u5e02\uff0c\u521b\u5386\u53f2\u65b0\u9ad8\uff0c\u800c\u7f8e\u56fd\u662f\u5176\u4e2d\u4e0a\u5e02\u65b0\u836f\u6570\u91cf\u6700\u591a\u7684\u56fd\u5bb6\uff0c\u5171\u4e0a\u5e02\u4e8672\u79cd NAS\uff0c44\u79cd\uff08\u8d85\u8fc760%\uff09\u88ab\u7f8e\u56fdFDA\u8bc4\u5b9a\u4e3a\u201c\u9996\u521b\u65b0\u836f\u201d\uff0c\u8d85\u8fc7\u4e00\u534a\u4ee5\u4e0a\u7684NAS\uff0840\u79cd\uff09\u83b7\u5f97FDA\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u7f55\u89c1\u75c5\u3002[4]<\/p>\n\n\n\n<p><strong>\u7814\u53d1\u9996\u521b\u65b0\u836f\u7684\u56f0\u96be<\/strong><\/p>\n\n\n\n<p>\u9996\u521b\u65b0\u836f\u867d\u7136\u5145\u6ee1\u7740\u66b4\u5229\u7684\u8bf1\u60d1\uff0c\u4f46\u5b83\u4e5f\u662f\u5e26\u523a\u7684\u73ab\u7470\u82b1\uff0c\u5916\u884c\u4eba\u5c11\u6709\u4eba\u77e5\u9053\u5176\u7814\u53d1\u5b58\u5728\u7684\u9ad8\u98ce\u9669\u3002\u65e9\u57282012\u5e74\uff0c\u6709\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u5236\u836f\u4e1a\u7684\u53cd\u6469\u5c14\u5b9a\u5f8b\uff1a\u5373\u7edf\u8ba11950-2010\u5e74\u95f4\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u6bcf10\u4ebf\u7f8e\u5143\u7684\u836f\u7269\u7814\u53d1\u8d39\u7528\u6295\u5165\uff0c\u83b7\u5f97\u7684\u7f8e\u56fdFDA\u6279\u51c6\u7684\u65b0\u836f\u6570\u91cf\u4e0d\u65ad\u5728\u51cf\u5c11\uff0c\u5927\u7ea6\u6bcf9\u5e74\u51cf\u534a\uff08\u53cd\u8fc7\u6765\u8bf4\u5c31\u662f\uff1a\u5927\u7ea6\u5341\u5e74\uff0c\u5176\u7814\u53d1\u8d39\u7528\u63a5\u8fd1\u7ffb\u500d\u7684\u901f\u5ea6\u5728\u589e\u52a0\uff09\u3002[5]<\/p>\n\n\n\n<p>\u5168\u7403\u751f\u7269\u6280\u672f\u884c\u4e1a\u7ec4\u7ec7BIO\u3001Informa Pharma Intelligence\u8054\u5408QLS\u53d1\u5e03\u7684\u62a5\u544a\u663e\u793a\uff0c2011\u5e74\u81f32020\u5e74\u7684\u5341\u5e74\u95f4\uff0c9704\u4e2a\u836f\u7269\u7814\u53d1\u9879\u76ee\u4e2d\uff0c\u6700\u540e\u7ecf\u8fc7FDA\u6279\u51c6\u4e0a\u5e02\u7684\u5e73\u5747\u6210\u529f\u7387\u7ea6\u4e3a7.9%\u3002<\/p>\n\n\n\n<p>2023\u5e744\u6708\uff0cJAMA 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is not the product of logical thought, even though the final product is tied to a logical structure\u201d\u4e00\u4e2a\u5916\u56fd\u4e13\u5bb6\u9053\u51fa\u5176\u4e2d\u7684\u5965\u5999\u3002&nbsp;\u7ffb\u8bd1\u7684\u610f\u601d\u5373\uff1a\u201d\u521b\u65b0\u4e0d\u662f\u7531\u903b\u8f91\u601d\u7ef4\u5e26\u6765\u7684\uff0c\u5c3d\u7ba1\u6700\u540e\u7684\u4ea7\u7269\u6709\u8d56\u4e8e\u4e00\u4e2a\u7b26\u5408\u903b\u8f91\u7684\u7ed3\u6784\u3002\u201d<\/p>\n\n\n\n<p>\u5982\u540c\u7f8e\u56fd\u54f2\u5b66\u5bb6\u5a01\u5ec9\u00b7\u8a79\u59c6\u65af\u7684\u603b\u7ed3\uff1a\u201c\u6bcf\u4e2a\u53d1\u73b0\u90fd\u8981\u7ecf\u5386\u4e09\u4e2a\u9636\u6bb5\uff1a\u5f53\u5b83\u9996\u6b21\u516c\u5e03\u65f6\uff0c\u4eba\u4eec\u8ba4\u4e3a\u8fd9\u662f\u4e0d\u6b63\u786e\u7684\u3002\u4e0d\u4e45\u4e4b\u540e\uff0c\u5f53\u4e8b\u5b9e\u5982\u6b64\u660e\u663e\u4ee5\u81f3\u4e8e\u4ed6\u4eec\u65e0\u6cd5\u518d\u5426\u8ba4\u65f6\uff0c\u4ed6\u4eec\u8ba4\u4e3a\u8fd9\u5e76\u4e0d\u91cd\u8981\u3002\u6b64\u540e\uff0c\u5982\u679c\u5b83\u7684\u91cd\u8981\u6027\u53d8\u5f97\u8db3\u591f\u660e\u663e\uff0c\u4eba\u4eec\u53c8\u4f1a\u8bf4\uff0c\u65e0\u8bba\u5982\u4f55\uff0c\u8fd9\u4e0d\u662f\u65b0\u7684\u53d1\u73b0\u3002\u201d<\/p>\n\n\n\n<p><strong>\u9996\u521b\u65b0\u836f\u7684\u4e16\u754c\u7ade\u4e89\uff0c\u4e2d\u56fd\u9009\u624b\u7684\u5fe7\u60a3<\/strong><\/p>\n\n\n\n<p>\u76ee\u524d\u4e2d\u56fd\u521b\u65b0\u836f\u4e2d\uff0c\u884c\u4e1a\u5171\u8bc6\u7684\u5206\u7c7b\u53ef\u4ee5\u5982\u4e0b\u51e0\u79cd\uff1a<\/p>\n\n\n\n<p>1\uff09\u9996\u521b\u65b0\u836f\uff08First-in-class\uff09\uff0c\u7f55\u89c1,\u9752\u84bf\u7d20\u7b97\u4e00\u4e2a,\u6216\u8005\u8bf4\u8fd1\u51e0\u5341\u5e74\u91cc\u6ca1\u6709\uff1b<\/p>\n\n\n\n<p>2\uff09\u540c\u7c7b\u6700\u4f18\uff08Best-in-class\uff09\uff0c\u6781\u4e3a\u5c11\u89c1\uff0c\u4e50\u89c2\u70b9\u767e\u6d4e\u795e\u5dde\u7684\u6cfd\u5e03\u66ff\u5c3c\uff0c\u5357\u4eac\u4f20\u5947\u7684\u897f\u8fbe\u57fa\u5965\u4ed1\u8d5b\u53ef\u4ee5\u7b97\u6b64\u7c7b\uff1b<\/p>\n\n\n\n<p>3\uff09\u4f18\u5316\u6a21\u4eff\uff08Me-better\uff09\uff0c\u4e5f\u5c11\uff1b\u516c\u5e73\u89c2\u70b9\u767e\u6d4e\u795e\u5dde\u7684\u6cfd\u5e03\u66ff\u5c3c\uff0c\u5357\u4eac\u4f20\u5947\u7684CAR-T\u4ea7\u54c1\u201c\u897f\u8fbe\u57fa\u5965\u4ed1\u8d5b\u201d\u53ef\u4ee5\u7b97\u6b64\u7c7b\uff1b<\/p>\n\n\n\n<p>4\uff09\u5feb\u901f\u6a21\u4eff\uff08Fast follow\uff09\uff0c\u56fd\u5185\u5927\u90e8\u5206\u7684\u521b\u65b0\u5c5e\u4e8e\u6b64\u7c7b\uff0c\u5df2\u7ecf\u6210\u4e3a\u5185\u5377\u91cd\u707e\u533a<\/p>\n\n\n\n<p>5\uff09\u4eff\u4e0d\u5982\uff08Me-below\uff09\uff0c\u4e2d\u56fd\u6709\u4f17\u591a\u7684\u5c0f\u4f01\u4e1a\uff0c\u884c\u4e1a\u4e13\u5bb6\u5927\u591a\u8ba4\u4e3a\u8fd9\u4e9b\u836f\u4f01\u7684\u4eff\u5236\u6c34\u5e73\u8fdc\u8fdc\u8fbe\u4e0d\u5230\u56fd\u9645\u516c\u53f8\u7684\u6807\u51c6\uff0c\u51fa\u6765\u7684\u4ea7\u54c1\u8d28\u91cf\u4ee4\u4eba\u582a\u5fe7<\/p>\n\n\n\n<p>\u603b\u7ed3\u4e00\u53e5\u8bdd\uff0c\u4e2d\u56fd\u76ee\u524d\u7684\u95ee\u9898\u662f\u5728\u505a\u76f8\u5bf9\u4f4e\u6c34\u5e73\u7684\u521b\u65b0\u836f\u7814\u53d1\u3002<\/p>\n\n\n\n<p>\u8fd15\u5e74\uff0c\u4ee5PD-1\/PD 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